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This drug causes an increase of one’s heart rate. There is a big risk in patients taking this drug with hypertension and arrhythmias. It has been reported that valvular heart disease may happen in patients taking this drug when combined with dexfenfluramine or fenfluramine. There was a report that 37 years old woman was admitted to the hospital having a ventricular fibrillation. This patient is under phentermine hydrochoride medication because of moderate obesity and she is also taking thyroid (USP) and trichlormethiazide. Her previous medical history is of no clinical importance. It was suspected that one of her medication contributed to her fatal arrhythmia.
There have been 2 reported incidents also where the patient is taking up phentermine and one of them is taking phendimetrazine together with this drug. One of them developed ischemic cerebrovascular disease. One experienced a cerebral infarct with angiographic traces that includes the multiple vascular beds. The other patient had headache and sensory disturbance with one week duration.
There was also a reported case of fatal pulmonary hypertension where the woman is taking the drug for 8 months and she is also taking up fenfluramine. The findings in the autopsy indicated severe pulmonary hypertension and she doesn’t have a history of smoking, no family history of hypertension.
A case of cardiomyopathy related to endocardial fibrosis is diagnosed after using phentermine in combination of fenteramine.
This drug causes nervous system stimulation that would lead into tremor, restlessness, anxiety, insomnia, dizziness and headache. There was a studies made that includes 50 women with refractory obesity and received the drug for a period of 20 weeks. Three defaulted in the study because she experienced headache without a change in blood pressure. Two patients also defaulted in relation to the irritability that they are experiencing.
There have been rare reported cases where patients had some psychotic episodes while taking the drug at the prescribed dose.
The adverse effects includes dry mouth, constipation/diarrhea and unpleasant taste.
Urticaria may likely to occur while taking this drug.